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The evaluation of compliance to antihypertensive therapy in patients after stroke and poststroke depression during antidepressant therapy

Author(s): B.B. Fishman | A.I. Khoroshevskaya | A.A. Abdulin | G.G. Semenova | P.V. Starikov | O.V. Pavlova

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 6;
Issue: 6;
Start page: 828;
Date: 2010;
Original page

Keywords: post-stroke depression | treatment compliance.

Aim. To study the effect of the antidepressant paroxetine on the compliance to antihypertensive therapy in patients with arterial hypertension (HT) and post-stroke depression.Material and methods. Patients (n=24) aged 55-73 with controlled HT (blood pressure, BP140/80 mmHg after 16 weeks was found in 10 (41.6%) patients. Clinical post-stroke depression was found in 7 (30.4%) patients, 5 (41.6%) of them were from group 2 (OR=0.35, 95% CI 0.12-0.78). High treatment compliance was in 15 (65.2%) patients, and 9 (81.8%) of them were from group 1. Nine (39.1%) patients did not receive an adequate antihypertensive therapy, 5 (41.6%) of them were from group 2 and could not explain their refusal from medication. General index of intellectual function was higher in patients of group 1 (p=0.034) than this in group 2; index of motor function did not change significantly (p>0.05).Conclusion. Reduction of compliance to antihypertensive therapy and rehabilitation in hypertensive patients after stroke is associated with unmotivated refusal from treatment because of clinical post-stroke depression.
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