Academic Journals Database
Disseminating quality controlled scientific knowledge

EVALUATION OF CONCOMITANT TREATMENT OF SIMVASTATIN AND ZINGIBER OFFICINALE IN DOXORUBICIN INDUCED CARDIOTOXICITY IN WISTAR RATS

ADD TO MY LIST
 
Author(s): Khatib N.A | Medi Swathi | Patel Jignesh

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 2;
Start page: 660;
Date: 2011;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Cardiotoxicity | Simvastatin | Zingiber officinale | Doxorubicin.

ABSTRACT
The present study was aimed to evaluate the combined effects of simvastatin (SIM) and ethanol extract of Zingiber officinale (ZO) in doxorubicin (DOX) induced cardiotoxicity in Wistar rats. DOX 10 mg/kg i.p single dose to causes cardiac damage and increases the levels of cardiac biomarker enzymes viz. ALT, AST, LDH and CKMB. In addition, a significant rise in HR, ST- segment and alterations in ECG patterns were observed in DOX treated group. SIM (1.8 mg/kg & 3.6 mg/kg) and ZO (200 mg/kg & 400 mg/kg) alone and in combination were given to rats as pretreatment for 30 days orally. Pretreatment with SIM and ZO alone significantly (P

Tango Jona
Tangokurs Rapperswil-Jona

     Affiliate Program