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Evaluation of the effect of taurine on cisplatin-induced hepatic injury and oxidative stress in male rats

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Author(s): Maryam Norozi Sarkarabad | Samad Zare

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 15;
Issue: 3;
Start page: 427;
Date: 2011;
Original page

Keywords: Cisplatin | Taurine | Hepatic injury | Antioxidant

ABSTRACT
Introduction: The principal dose-limiting factor in the use of cisplatin as an antineoplastic drug is its hepatic toxicity. This study was designed to investigate the protective role of taurine against cisplatin-induced hepatic injury. Methods: Male albino rats (180-220 g) were divided in to 4 groups (n=8) as follows: (1) saline-treated group (2): cisplatin-treated group (10 mg/kg ip) (3): group that received taurine (200 mg/kg ip) for 1hr before cisplatin (10 mg/kg ip) administration (4): taurine treated group (200 mg/kg ip). After 7 days, the animals were sacrificed and blood samples collected from the heart as well as liver tissues were kept at -70 °C till further analyses. Results: analyses showed that cisplatin significantly increased ALT and AST serum levels (P
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