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Evaluation of the effects of taurine on cisplatin-induced kidney injury and oxidative stress in male rats

Author(s): maryam noruzi | samad zareh

Journal: Physiology and Pharmacology
ISSN 1735-0581

Volume: 15;
Issue: 4;
Start page: 478;
Date: 2012;
Original page

Keywords: cisplatin | taurine | kidney injury | rat

Introduction: Cisplatin is used as a chemotherapeutic agent for the treatment of human ovarian and testicular cancers. This study was designed to investigate the protective role of taurine against cisplatin-induced kidney injury. Methods: Male Wistar rats were divided into 4 groups (n=8) (1) saline-treated group (2) cisplatin-treated group (10 mg/kg, i.p.), (3) group that received taurine (200 mg/kg, i.p) 1 hr before cisplatin (10 mg/kg, i.p) administration and (4) taurine treated group (200 mg/kg, i.p). The treatment period was 7 days. Animals were then weighed and blood samples were collected from the heart. After sacrifice, kidneys were removed and kept at -70 °C until further analyses. Results: Cisplatin significantly elevated the creatinine and blood urea nitrogen (BUN) serum levels (P
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