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Evaluation of Enzymes Inhibition Activities of Medicinal Plant from Burkina Faso

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Author(s): Mindiediba Jean Bangou | Martin Kiendrebeogo | Nag-Tiero Roland Meda | Ahmed Yacouba Coulibaly | Moussa Compaore | Boukare Zeba | Jeanne Millogo-Rasolodimby | Odile Germaine Nacoulma

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 14;
Issue: 2;
Start page: 99;
Date: 2011;
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Keywords: acetylcholinesterase | glutathione-s-transferase | Polyphenolic compounds | carboxylesterase | xanthine oxidase

ABSTRACT
The aim of the present study was to evaluate some enzymes inhibitory effects of 11 plant species belonging to 9 families from Burkina Faso. Methanolic extracts were used for their Glutathione-s-transferase (GST), Acetylcholinesterase (AChE), Carboxylesterase (CES) and Xanthine Oxidase (XO) inhibitory activities at final concentration of 100 μg mL-1. The total phenolics, flavonoids and tannins were also determined spectrophotometrically using Folin-Ciocalteu, AlCl3 and ammonium citrate iron reagents, respectively. Among the 11 species tested, the best inhibitory percentages were found with Euphorbia hirta, Sclerocarya birrea and Scoparia dulcis (inhibition>40%) followed by Annona senegalensis, Annona squamosa, Polygala arenaria and Ceratotheca sesamoides (inhibition>25%). The best total phenolic and tannin contents were found with S. birrea with 56.10 mg GAE/100 mg extract and 47.75 mg TAE/100 mg extract, respectively. E hirta presented the higher total flavonoids (9.96 mg QE/100 mg extract). It's was found that Sclerocarya birrea has inhibited all enzymes at more than 30% and this activity is correlated to total tannins contents. Contrary to S. birrea, the enzymatic activities of E. hirta and S. dulcis are correlated to total flavonoids contents. Present findings suggest that the methanolic extracts of those plant species are potential inhibitors of GST, AChE, CES and XO and confirm their traditional uses in the treatment of mental disorders, gout, painful inflammations and cardiovascular diseases.
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