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Evaluation of genotoxic effects of ipronidazol, Gastrogal 10R, in cultures of human peripheral blood lymphocytes

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Author(s): Marković Biljana 1 | Stanimirović Zoran Ž. | Đelić Ninoslav J. | Anđelković M.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 52;
Issue: 4;
Start page: 273;
Date: 2002;
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Keywords: chromosome aberrations | Gastrogal 10 | ipronidazol | SCE

ABSTRACT
In this work, we examined the genotoxic effect of the antibiotic preparation ipronidazol (Gastrogal 10). An experiment was performed in vitro on human peripheral blood lymphocytes using the chromosome aberration and sister chromatid exchange tests. Clastogenic effects of ipronidazol were examined at three experimental concentrations (25 (g/ml, 50 (g/ml i 100 (g/ml) in eight experimental cycles. The results demonstrate that Gastrogal 10 has the ability to change the human lymphocyte kariotype, i.e. it induces numerical aberrations (aneuploidies and polyploidies), as well as chromosome gaps and breaks. Moreover, Gastrogal 10 induces a significant increase of sister chromatid exchange in human lymphocytes. The obtained results demonstrate that the examined preparation exhibits a certain genotoxic potential.
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