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Evaluation of Ghrelin Levels in Polycystic Ovary Syndrome and the Correlation with Obesity, Insulin Resistance and Other Biochemical Features

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Author(s): Kun Shi | Balsam Habeeb Jasim | Xuecheng Shao

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 3;
Issue: 5;
Start page: 218;
Date: 2011;
Original page

Keywords: Body mass index | ghrelin | homeostasis model assessment | polycystic ovarian syndrome

ABSTRACT
Ghrelin is new peptide might be associated with common features of polycystic ovary syndrome (PCOS) like insulin resistance and adiposity. Irregularities of ghrelin levels in PCOS contributed to the many physiological problems as (obesity and energy balance). The purpose of this work was to evaluate the ghrelin levels in women with polycystic ovary syndrome and control and secondarily assessed the correlation of ghrelin levels with obesity and insulin resistance. Serum ghrelin levels were compared between 57 Chinese women have PCOS were divided into two groups according to their body mass index (BMI): 30 overweight/obese PCOS and 27 non obese PCOS and 20 healthy controls. The correlation between ghrelin levels and other hormones was investigated. Anthropometric measurements were made for all subjects. Biochemical and hormonal investigations included plasma glucose, insulin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), testosterone and insulin resistance was measured by using Homeostasis Model of Assessment of Insulin Resistance (HOMA-IR). Serum ghrelin levels were measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Plasma ghrelin levels were significantly decreased in overweight/obese PCOS compared to non-obese PCOS and control group. Fasting insulin levels and HOMA-IR were significantly higher in theoverweight/obese group compared to control. Significant inverse correlation was observed between ghrelin levels and BMI in both overweight/obese PCOS and control (r = -0.71, p
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