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EVALUATION OF HEPATOPROTECTIVE EFFECT OF CALOTROPIS PROCERA (AIT) R.BR ROOT EXTRACT AGAINST CCL4 INDUCED HEPATO-OXIDATIVE STRESS IN ALBINO RATS

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Author(s): Patil Prakash | K Prasad | M Nitin | M Vijay Kumar | K Sreenivasa Rao

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 1;
Start page: 319;
Date: 2011;
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Keywords: Calotropis procera | CCL4 | Hepatoprotective activity | Albino rats.

ABSTRACT
In the present study, Calotropis procera (Asclepediaceae) was evaluated for its possible hepatoprotective and antioxidant potential. Hepatoprotective activity of the methanol extract (MCP) of the root bark was determined using carbon tetrachloride (CCl4) induced liver injury in rats. MCP extract evaluated, at an oral dose of 200 and 400 mg kg1. The animals were weighed each and divided in groups of six. Liver damage was achieved by injecting CCl4 in olive oil (1:1) 0.8 mL kg-1. The treatment groups pretreated with above extracts. Silymarin was used as reference standard drug. At the end of 7 days, blood was collected, liver extracted, weighed, processed for histopathological assessments and for antioxidant activity. The MCP exhibited a significant (p
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