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Evaluation of Humoral Immune Function in Patients with Chronic Idiopathic Thrombocytopenic Purpura

Author(s): Mohammad Saeid Rahiminejad | Mehrdad Mirmohammad Sadeghi | Payam Mohammadinejad | Bamdad Sadeghi | Hassan Abolhassani | Mohammad Mehdi Dehghani Firoozabadi | Seyed Mohammad Fathi | Hamid Rezvani | Gholamreza Bahoush | Mohammad Ali Ehsani | Mohammad Faranoush | Azim Mehrvar | Babak Torabi Sagvand | Mojtaba Ghadiani | Nima Rezaei | Asghar Aghamohammadi

Journal: Iranian Journal Of Allergy, Asthma and Immunology
ISSN 1735-1502

Volume: 12;
Issue: 1;
Start page: 50;
Date: 2013;
Original page

Keywords: Idiopathic | Immunologic Deficiency Syndromes | Purpura | Splenectomy | Thrombocytopenic

Coincidence of autoimmune diseases such as immune thrombocytopenic purpura (ITP)with immunodeficiencies has been reported previously in patients who suffered from primary antibody deficiency (PAD). But there is no original study on immunological profilesof ITP patients to find out their probable immune deficiency.In this case-control study, ITP patients’ humoral immunity was investigated for diagnosis of PAD in comparison with normal population. To evaluate the humoral immune systemagainst polysaccharide antigens, patients’ serum immunoglobulin levels were measured and a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) was administrated toevaluate the antibody response to vaccination.In this study, 14 out of 36 patients (39%) were diagnosed with antibody mediated immune deficiency including 2 patients (5.5%) with immunoglobulin class deficiency and 4 (11%) with IgG subclass deficiency. The remaining patients suffered from specific antibodydeficiency. The most frequent deficiency in ITP patients was specific antibody deficiency.Therefore, immunological survey on ITP patients may be important especially for those who have undergone splenectomy.

Tango Jona
Tangokurs Rapperswil-Jona

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