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Evaluation of Hydroxyl radical scavenging activity and HPTLC fingerprint profiling of Aegle marmelos (L.) Correa extracts.

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Author(s): P V.Bramhachari1, J. Ravichand2, YHK Reddy3, D. Kotresha4, K. Viswanatha Chaitanya5 and Varaprasad Bobbarala6*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 1;
Start page: 252;
Date: 2011;
Original page

Keywords: Aegle marmelos (L.) Correa | Scavenging activity | Hydroxyl radical | Lipid peroxidation | HPTLC

ABSTRACT
Aegle marmelos (L.) Correa has been widely used in indigenous systems of Indian medicine due to its various medicinal properties. The hydroxyl radical producing compound of the root extract showed 53%, whereas the leaf extract showed only 28% scavenging activity. Scavenging activity of A. marmelos extracts of root and leaf is inversely proportional to the free radical production. Interestingly the result of the present study revealed that the root extractsshowed significantly less free radical activity as compared to leaf extracts. The percentage of lipid peroxidation per inhibition with A. marmelos root and leaf extracts also demonstrated that root extracts (49% inhibition) showed more scavenging activity or inhibition of free radical scavenging activity compared to leaf extracts (32% inhibition). The HPTLC spectrum at 254nm revealed 14 peaks in both roots and leaf extracts. The UV spectrum showed maximumabsorbance at wavelength of 366nm. The percentage of umbelliferone obtained from the root extract was 0.016645%, however the percentage of leaf extract was 0.005628% as confirmed by HPTLC. The results obtained from the current study suggest that A. marmelos root extract is a potential source of natural antioxidant.
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