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EVALUATION OF IL1-α AND TNF-α SERUM LEVELS IN RHEUMATOID ARTHRITIS PATIONTS WITH ACTIVE AND INACTIVE, WITH OR WITHOUT BONE EROSION

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Author(s): AR. Rostamian | AH. Naji | F. Gharibdoost | A. KHalvat | L. Jafari Saraf K. Saeedfar

Journal: Acta Medica Iranica
ISSN 0044-6025

Volume: 45;
Issue: 6;
Start page: 487;
Date: 2007;
Original page

Keywords: cytokins

ABSTRACT
Rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. Several studies in recent years were conducted for evaluation of inflammatory cytokines such as IL1-α (Interlukin 1α) and TNF- α (Tumor necrosis factor) in rheumatologic disorders including rheumatoid arthritis to find new treatment methods base to pathogenesis. In this study different serum levels of IL1-α and TNF- α in 160 rheumatoid arthritis patients with active and inactive disease and also disease with or without bone erosion are assessed. 4% of our patients had rheumatoid nodule and 70% of all patients had positive RF, IL1-α, and TNF- α levels. Active with bone erosion patients had IL1-α and TNF- α serum levels higher than active without bone erosion patients; it was not significant in T-test but it was significant in Mann-Whitney Test. The results was the same as expected; IL1-α, and TNF- α serum levels were higher in active with bone erosion in comparison with inactive without bone erosion patients.
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