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Evaluation of immunomodulatory potential of ethanolic extract of Roscoea procera rhizomes in mice

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Author(s): Sahu Mahesh | Mali Prashant | Waikar Shekhar | Rangari Vinod

Journal: Journal of Pharmacy and Bioallied Sciences
ISSN 0975-7406

Volume: 2;
Issue: 4;
Start page: 346;
Date: 2010;
Original page

Keywords: Cell-mediated immunity | delayed-type hypersensitivity response | humoral immunity | Roscoea procera | rhizomes

ABSTRACT
Purpose : The aim of present study was to evaluate immunomodulatory potential of ethanolic extract of Roscoea procera (Zingiberaceae) rhizomes by using delayed-type hypersensitivity (DTH) and carbon clearance method in comparison to standard established immunosuppressant drug, cyclophosphamide (30 mg/kg, i.p.) in mice. Material and Methods : The extract was comprised to acute toxicity (OECD-423 guideline), DTH and carbon clearance method for their immunomodulatory potential. Ethanolic extract of Roscoea procera rhizomes administered orally at doses 300 mg/kg and 600 mg/kg, p.o. to mice. Result and Conclusion : Result of our study revealed that, the foot pat thickness of ethanolic extract group (P
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