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Evaluation of the implant-bone interface integration using PRGF in the dog jaw

Author(s): Mohammad Tavakoli | Reza Birang | Ali Rafidargahi | Ali Rafie Dargahi | Ali Reza Torabi

Journal: Journal of Isfahan Dental School
ISSN 1735-255X

Volume: 6;
Issue: 4;
Start page: 357;
Date: 2011;
Original page

Keywords: Key words: Animal study | Dental implants | Growth factor | Histomorphometry | Histology | Plasma.

Introduction: It has been demonstrated that use of plasma rich in growth factors produces a dynamic surface on the implants, which accelerates the healing process. This study undertook a histologic and histomorphometric evaluation of the effect of platelet-rich growth factors (PRGF) on the amount of bone regeneration around dental implants.Materials and Methods: In this animal-intervention study, two systemically healthy Persian mix-breed dogs were selected. Three months after extraction of the dogs’ mandibular premolars on both sides, 12 implants were selected from the OIC system with a length of 10 mm and a diameter of 5 mm. Six implants were placed in the osteotomy cavities using growth factors and 6 others were placed in the osteotomy cavities without PRGF. After 12 weeks, all the implants were removed along with the surrounding bone using Trephine bur. The samples were evaluated under a light microscope subsequent to sectioning. Data were analyzed with t-test and Mann-Whitney test (α = 0.05).Results: The results of the present study indicated that histologically, there was a significant increase in the amount of regenerated bone around the implants; moreover, thickness and maturity of bony trabeculae were not different in the samples containing PRGF in comparison with the control samples.Conclusion: According to the results, implant-bone interface integration rate around dental implants coated with PRGF was higher compared to the control group Key words: Animal study, Dental implants, Growth factor, Histomorphometry, Histology, Plasma.
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