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EVALUATION OF METHANOLIC EXTRACT OF CASSIA FISTULA BARK FOR CARDIOPROTECTIVE ACTIVITY

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Author(s): Khatib N. A. | Wadulkar R. D. | Joshi R. K | Majagi S.I.

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 1;
Issue: 2;
Start page: 565;
Date: 2010;
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Keywords: Cardioprotective | Cassia fistula | vitamin E | doxorubicin

ABSTRACT
Cassia fistula of the family Leguminaceae is traditionally used in cardiopathy and heart disease. The cardioprotective effect of the methanolic extract of C. fistula (MECB) bark against doxorubicin (DXR) induced cardiotoxicity in wistar rat was studied. DXR 10 mg/kg i.p. single dose to male Wistar rats causes cardiac damage and increases the levels of cardiac biomarker enzymes Viz. AST, ALT, LDH and CKMB. The histopathological changes in DXR treated animals showed sever degeneration of the myofibrils with focal necrosis and vacuolated cytoplasm. Pretreatment with MECB at a dose of 400 mg/kg significantly decreased the elevated levels of serum enzymes histological disturbances and electro cardiogram changes to normal myocardium functioning. The result suggests that MECB has cardio protective effect in DXR induced myocardial damage rats.

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