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Evaluation of the physical and functional development in recently born rats for their use in perinatal and postnatal study

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Author(s): Daniel Francisco Arencibia Arrebola | Luis Alfredo Rosario Fernández | Yulieé López Feria | Lisset Ortiz Zamora | Dayisell Lazara Curveco Sánchez

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 22;
Start page: 16;
Date: 2009;
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Keywords: Physical development | sensorial and motor development | behavior | recently born rats

ABSTRACT
The three studies design that they embrace of direct or indirect form all the stage of the reproduction process, is considered that it is the most appropriate for the evaluation of most medicinal products and vaccine. They should be kept in mind all the pharmacological, kinetic data, and toxicologics to decide which of the studies they will be carried out. The most probable option is the studies combination of, fertility and the early embryonic development, prenatal and postnatal development including the reproductive function and the embriofetal development. The study of prenatal and postnatal effects on the development which is of the one that concerns us to speak, in this article detects the toxic effects in the female during the pregnancy and the lactation and that taken place in the breedings by the exhibition of the mothers from the implantation until the wean. This study is carried out at one species, preferably the rat. These procedures are applied to determine the effects on the breedings of the treatments given to their parents. In the same one is detailed a methodology to evaluate the physical and functional development of rodents from the birth until the wean. The different parameters that are described in this work, it refers to the physical development, sensorial and motor development and the behavior, in rat. Each one of the described parameters, usually appears in rat at a concrete age margin, for what varies the observation moment.
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