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EVALUATION POTENTIAL OF VALERIAN ROOTS EXTRACT AND VALEPOTRIATES ON BEHAVIORAL TESTS IN MICE

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Author(s): Edvaldo Rodrigues de Almeida | Haroudo Sátiro Xavier | Aluizio Roberto da Silva | Thais Malheiros Chaves | Adelmo Cavalcanti Aragão-Neto

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 5;
Start page: 164;
Date: 2011;
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Keywords: Anti-Anxiety | Behavior | Valerian officinalis | Mice

ABSTRACT
This study was to evaluate the effect of Valerian extract marketed in Recife PE Brazil and Valepotriates and their actions in the CNS in mice. Intraperitoneal administration were used to assess the hypnotic effect (Sodium Pentobarbital-Induced Sleeping Time), anxiolytic (Elevated plus-maze, Hole-board, Marble burying), and the observation of possible anticonvulsant activity (seizures induced by Pentylenetetrazol), using doses of 50, 100 and 200 mg / kg for the extract and 12 mg/kg for Valepotriates. Data indicate an anxiolytic action, and hypnotic only by the intraperitoneal route, but oral administration showed no significant effect on the behavioral tests (data not shown). This study demonstrated an anxiolytic and hypnotic action extract of Valeriana officinalis, as well as the Valepotriates at a dose of 12 mg/kg.
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