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Evaluation of prevalence and patterns of bone metastases in locally advanced breast Cancer patients

Author(s): Fatemeh Fatemeh Homaei | Fatemeh Nosrati | Mohammad Afshari

Journal: Iranian Journal of Nuclear Medicine
ISSN 1681-2824

Volume: 18;
Issue: Suppl 1;
Start page: 147;
Date: 2010;
Original page

Keywords: Bone metastases | Breast cancer | Bone scan.

Introduction: According to routine clinical observations, Iranian breast cancer patients refer with advanced stages and skeletal system is the most common site of metastases, among them Objective: This study is aimed to evaluate the frequency and patterns of bone metastases in new locally advanced breast cancer patients, before treatment. Materials and Methods: A descriptive study was done on 30 patients with locally advanced Breast cancer (all T4,T3,N1,N2,N3 ) retrospectively, referred to Ghaem hospital from 2005 to 2010. In all patients result of Bone Scan, X-Ray imaging, tumor markers (CEA,CA15-3)and serum ALP enzyme were collected. Results: The mean age of patients was 47.8y. Bone metastases were found in 6 (20%) patients. The most common sites of bone involvement were lumbar and thoracic vertebrae and Ribs respectively. In patients with positive bone scan, 5 (83%) patients have X-Ray abnormalities, 4 (66%) patients have raised tumor markers, all (100%) patients were menopause, all (100%) patients have ductal carcinoma pathology, and none of patients have raised Alp. Conclusion: Frequency and patterns of bone metastases in locally advanced breast cancer among our patients were similar to most of other studies, which occurred in the world.
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