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Evaluation of the Proposed Inhibitory Effect of the Aqueous Stem-Bark Extract of Ficus exasperata on Uterine Preparations in vitro

Author(s): E.E. Bafor | M. Nwiko | E.K.I. Omogbai | R.I. Ozolua | Z.A.M. Nworgu

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 5;
Issue: 1;
Start page: 94;
Date: 2009;
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Keywords: Ficus exasperata | uterine segments | pre-term contraction | oxytocin-induced contraction | uterine inhibition

The effect of the aqueous stem-bark extract of Ficus exasperata (ASE) was studied on oxytocin- and acetylcholine-induced uterine contractions in uterine preparations isolated from non-pregnant Sprague-Dawley rats in oestrus. Preliminary phytochemical analysis was also performed. There were no statistically significant increases in the concentrations of oxytocin and acetylcholine required to elicit 30 and 50% of maximum response (EC30 and EC50, respectively) in the presence of the extract. Salbutamol and atropine, however, significantly inhibited the effects of oxytocin and acetylcholine, respectively. Phytochemical analysis revealed the presence of alkaloids, tannins and saponin glycosides. These results indicate that ASE possesses no inhibitory effect on the non-pregnant rat uterus as claimed by traditional healers.
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