Author(s): Ray S | Roy K | Sengupta Chandana
Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X
Volume: 69;
Issue: 3;
Start page: 378;
Date: 2007;
Original page
Keywords: Lipid peroxidation | Spirulina platensis | cisplatin | malondialdehyde | reduced glutathione | 4-hydroxy-2-nonenal | nitric oxide.
ABSTRACT
Attempt has been made to evaluate free radical scavenging activity of water extract of Spirulina platensis on cisplatin-induced lipid peroxidation using some common laboratory markers. In this present study goat liver has been used as lipid source. This in vitro evaluation was done by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide content of tissue homogenates. The results suggest that cisplatin could induce lipid peroxidation to a significant extent and it was also found that water extract of the algae has the ability to suppress the cisplatin-induced toxicity.
Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X
Volume: 69;
Issue: 3;
Start page: 378;
Date: 2007;
Original page
Keywords: Lipid peroxidation | Spirulina platensis | cisplatin | malondialdehyde | reduced glutathione | 4-hydroxy-2-nonenal | nitric oxide.
ABSTRACT
Attempt has been made to evaluate free radical scavenging activity of water extract of Spirulina platensis on cisplatin-induced lipid peroxidation using some common laboratory markers. In this present study goat liver has been used as lipid source. This in vitro evaluation was done by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide content of tissue homogenates. The results suggest that cisplatin could induce lipid peroxidation to a significant extent and it was also found that water extract of the algae has the ability to suppress the cisplatin-induced toxicity.
