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Evaluation of radioprotective effect of bischalcone derivative using Drosophila melanogaster (Oregon K) model system

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Author(s): C. G. Darshan Raja*, B. K Sarojini a, M.K. Ramakrishnab, S.R. Rameshb, B.Narayanac, Ganesh Sanjeevd

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 7;
Start page: 2012;
Date: 2011;
Original page

Keywords: bischalcone derivative/ drosophila melanogaster/ electron beam radiation/ radioprotection/ oxidative stress markers.

ABSTRACT
A synthetic bischalcone derivative [(2E, 5E)-2,5-bis (3-methoxy-4-hydroxy-benzylidene) cyclopentanone (B) was evaluated for the radioprotective effect on electron beam radiation induced oxidative stress in Drosophila melanogaster (Oeragon K) strain adults male flies. Curcumin (CU) was taken as standard as the structure of bischalcone resembles curcumin. The oxidative stress markers employed in the study included lipid peroxidation products malondialdehyde (MDA) and hydroperoxide (HP), reduced glutathione (GSH) and antioxidant enzymes included superoxide dismutase (SOD) and catalase (CAT). The oxidative stress was induced at 1.5Gy electron beam. The concentration of compound for treatment was fixed based on LC50 values. There was significant demolition in the levels of MDA and HP. The level of SOD and CAT was brought to near basal level in the homogenate of flies which were pretreated with B and irradiated. In most of the studies the compound B exhibited better activity than CU in dose dependent manner.
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