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Evaluation of the radioprotector effect of the aqueous extract of Mangifera indica L (Vimang), in SOS-Chromotest assays.

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Author(s): Luis Alfredo Rosario Fernández | Idania Rodeiro | Eliseo Almeida | Daniel Francisco Arencibia | Osney Leyva | Alena Alonso | Yanet Rodriguez

Journal: RETEL : Revista de Toxicología en Línea
ISSN 1668-091X

Volume: 19;
Start page: 53;
Date: 2009;
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Keywords: Mangifera indica L | radioprotector | strains | E.coli PQ-37 | SOS

ABSTRACT
The ionizing radiations are use with success in the treatment against the cancer and other illnesses. For it, a growing interest exists in developing new products with radioprotector character that diminish the adverse effects of the radiotherapy. The aminotioles (as the amifostina) they are agents that more they have been used with thispurpose; however they cause severe secondary effects. For this reason, the current tendency is focused to obtaining the radioprotector compounds from natural sources. The natural product, Vimang to obtains starting from the bark of Mangifera indica L, itconstitutes a interesting candidate for the character radioprotector evaluation if one keeps in mind that the pharmacological studies carried out until the moment, which corroborate their effectiveness like antinflammatory, analgesic, inmunomodulator and antioxidant. Some of the characteristics that have been mentioned by different authors like properties of an ideal radioprotector. The aim of this work is to evaluate the radioprotector effect of the aqueous extract of M. indica L (Vimang), front gamma radiation, by means SOS-Chromotest bacterial assays, to a 150 Gy dose of radiation. This assays indicated that the extract is not genotoxic in the analyzed range of concentrations (50, 250, 500 and 1000 g/mL); in presence or not of metabolic activation. We conclude that this product is able to protect the cellular structure at the nuclear material level, of the damages induced by the gamma radiation to the doses studied in the SOS Chromotest assays.
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