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Evaluation of schistosomicidal and leishmanicidal activities from Carica papaya (Linn.) stem and phytochemical composition

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Author(s): Khaled Nabih Rashed | Michele Garcia da Cruz | Geovana Pereira Guirra Vieira | Lizandra Guidi Magalhaes | Wilson R. Cunha

Journal: Topclass Journal of Herbal Medicine
ISSN 2315-8840

Volume: 2;
Issue: 10;
Start page: 239;
Date: 2013;
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Keywords: Carica papaya | stems | schistosomicidal activity | leishmanicidal activity

ABSTRACT
Carica papaya Linn., is a member of the small family Caricaceae. Each part of papaya tree possesses economic value and is considered as a valuable nutraceutical fruit plant. C. papaya has a wide range of purported medicinal properties including antiseptic, antiparasitic, anti inflammatory, antidiabetic and contraceptive activity. While there are only limited data to support most of these uses, there are some evidences for their use in healing decubitus ulcers and other wounds and in treating intestinal worms in humans. It can be chosen as a source of papain for the development of various industrial and pharmaceutical products for various diseases. This present study was carried out to evaluate schistosomicidal and leishmanicidal activities and also to investigate the phytochemical composition of the C. papaya methanol extract. The extract was tested using Schistosoma mansoni and Leishmania amazonensis assays. The results showed that C. papaya methanol extract has a little or no activity against S. mansoni or L. amazonensis. Against S. mansoni, the extract showed no lethal effect, but a reduction in the motor activity at highest concentrations was observed. On the other hand, against L. amazonensis, the extract caused lysis of only 15.3±4.6 of parasites at the concentration of 400 µg/mL. Phytochemical analysis of 80% methanol extract of C. papaya stem showed the presence of flavonoids, tannins, alkaloids, carbohydrates and triterpenes. This is the first report about the schitosomicidal and leishmanicidal activities of C. papaya stems methanol extract and its chemical composition, particularly triterpenes which have shown significant schitosomicidal and leishmanicidal activities
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