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Evaluation of sympathetic skin responses associated with the autonomic nervous system and fatigue scores in patients with multiple sclerosis

Author(s): Şeyda Bayil Yetik | Emine Rabia Koç | Ali Kemal Erdemoğlu

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 3;
Issue: 3;
Start page: 387;
Date: 2012;
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Keywords: Multiple Sclerosis | autonomic nervous system | sympathetic skin response | fatigue

Objectives: In this study we aimed to investigate the effectof autonomic dysfunction on quality of life and symptomsof fatigue patients with MS.Materials and methods: The study included 30 patientswith MS and 35 healthy subjects as control group. Disabilitywas assessed using the Expanded Disability StatusScale (EDSS); autonomic functions were assessedby SSR; fatigue symptoms were assessed by FatigueDescriptive Scale (FDS); effect of autonomic dysfunctionon quality of life and fatigue symptoms was assessed bySF-36 scale.Results: There was no significant difference between theleft hand SSR latency, mean amplitude and area betweenpatient and control groups. Mean FDS value was significantlyhigher in MS group. SSR amplitude and area weresignificantly smaller in patients which received prophylactictreatment. There was no relation between the FDSscores and SSR values in patients receiving prophylaxis.In the patient group, a positive correlation was detectedbetween EDSS and FDS score; and significantly negativecorrelation between pyramidal, cerebellar and spasticity;a significant positive correlation was found between amplitudeand the size of area of the SSR and brain stemfunctions. There was no significant relationship betweenFDS with SSR area, latency and amplitude.Conclusions: SSR measurements are not sensitive inorder to evaluate autonomic dysfunction in patients withmultiple sclerosis. Symptoms of fatigue has a negativelyaffect on the activity of the patient’s daily life. SSR testis not sufficient to show the relationship between fatigueand autonomic dysfunction. J Clin Exp Invest 2012; 3 (3):387-391Key words: Multiple Sclerosis, autonomic nervous system,sympathetic skin response, fatigue.
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