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Evaluation of the Synergetic Effect of Water Soluble Extracts of Green Tea (Camellia sinensis) on the Activity of Ciprofloxacin in Urinary Isolated E. coli

Author(s): Nima Hosseini Jazani | Minoo Zartoshti | Shahram Shahabi | Zahra Yekta | Shahin Nateghi

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 7;
Issue: 8;
Start page: 1500;
Date: 2007;
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Keywords: ciprofloxacin | minimum bactericidal concentration | minimum inhibitory concentration | Green tea | E. coli | synergetic effect

The aim of this study is the evaluation of the synergistic effect of sub-MIC doses of ciprofloxacin with water soluble green tea extract against urinary tract isolates of E. coli. A total of 18 isolates were collected from urine specimens submitted to a clinical diagnostic Laboratory in Urmia, Iran. The amounts of MIC and MBC for green tea water extract, ciprofloxacin or a mixture of green tea with sub-MIC doses of ciprofloxacin were determined and three groups were compared. The Synergism between ciprofloxacin and water soluble green tea extracts were seen for 93.7% (15 of 16 tested) of bacterial isolates. This study suggests that combination of water soluble green tea extracts and ciprofloxacin has in vitro synergistic effect on urinary tract isolated E. coli.
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