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Evaluation of ultrasonographic fatty liver and severity of coronary atherosclerosis, and obesity in patients undergoing coronary angiography

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Author(s): Mahmut Açıkel | Sadık Sunay | Mustafa Koplay | Fuat Gündoğdu | Şule Karakelleoğlu

Journal: Anadolu Kardiyoloji Dergisi
ISSN 1302-8723

Volume: 09;
Issue: 05;
Start page: 273;
Date: 2009;
Original page

Keywords: Coronary artery atherosclerosis | non-alcoholic fatty liver disease | obesity | predictive models

ABSTRACT
Objective: Aims were to examine associations (1) between non-alcoholic fatty liver disease (NAFLD) and the presence and severity of coronary artery disease (CAD) and obesity, (2) between CAD and NAFLD with aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamiltransferase (GGT) levels.Methods: In this cross-sectional study, the study group consisted of 355 patients (mean age: 57.5±11.4 years), that comply with inclusion criteria and selected of 414 consecutive patients who underwent coronary angiographies. Coronary artery disease was defined as a stenosis at least 50% in at least one major coronary artery. Modified Gensini scoring was used to determine the severity of coronary atherosclerosis. Fatty liver was diagnosed by abdominal ultrasonography (4 stages: Grades 0, 1, 2 and 3). Obesity was defined as body mass index (BMI)≥30 kg/m2. Statistical evaluations were performed using Student’s t test, ANOVA, Chi- square, kappa tests and logistic regression analysis. Results: There were significant differences among Grades 0, 1 and 2-3 according to presence of CAD and Gensini score. In univariate analysis, age (OR=1.03, p=0.004), gender (OR=3.05, p
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