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Evidence for Positive Effects of Date Extract That Attenuates Thermal Hyperalgesia in a Diabetic Rat Model of Neuropathic Pain

Author(s): Mohammad Shabani | Nasser Zangiabadi | Majid Asadi-Shekaari

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 04;
Issue: 01;
Start page: 16;
Date: 2013;
Original page

Keywords: Date Extract | Diabetic | Melatonin | Neuropathic Pain | Thermal Hyperalgesia

Diabetic neuropathic pain is one of the pains which hardly respond to pharmaceutical treat. Today, various chemical and herbal compounds have been used to reduce pain. The aim of this study is to compare the effect of date extract and melatonin in preventing pain in diabetic rats.Method: tonin [10 mg/kg/day, intraperitoneally (i.p.)] for a period of 6 weeks. At the end of the sixth week, control and treated rats were examined by thermal pain response and explorative activity tests.Results:sponse time to thermal pain in treated group showed a significant decrease in comparison with the control group (P0.01). Prescription of date extract increased response time to thermal pain in comparison with treated group (P0.01), so that response time approximated to control group. Although melatonin approximated to the response time to control group, the significant difference was not observed among melatonin receivers and other groups. In the assessment of diabetic neuropathy on the explorative activity of rats in an open field behavioral test, total distance moved and rearing frequency were significantly decreased, while administration of date extract did also improve motor deficits induced by STZ.Conclusions:
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