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AN EXPEDITIOUS, EFFICIENT AND GREEN SYNTHESIS OF SOME 2-ARYLBENZOXAZOLES CATALYZED BY PTSA UNDER SOLVENT-FREE CONDITION

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Author(s): Vinod Kumar, Girish Kumar Gupta Akhilesh Kumar Gupta

Journal: Current Trends in Biotechnology and Chemical Research
ISSN 2249-4073

Volume: 1;
Issue: 1;
Start page: 49;
Date: 2012;
Original page

ABSTRACT
A simple, efficient and rapid procedure for the preparation of various 2-substituted benzoxazoles (3) has been developed. The reaction of o-aminophenol with various substituted aromatic aldehydes proceeds smoothly in the presence of p-toulene sulfonic acid (PTSA) as a solid catalyst at room temperature. The products were obtained in excellent yield in very short time. Mild reaction conditions, clean reaction media, simple workup and easy purification are advantages of this methodology.
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