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AN EXPERIMENTAL EVALUATION OF ANTICONVULASANT ACTIVITY OF NERIUM OLEANDER LEAF EXTRACT

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Author(s): Rout Susanta Kumar | Kar Durga Madhab

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 10;
Start page: 73;
Date: 2011;
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Keywords: Anticonvulsant | Nerium oleander | Maximal Electroshock seizure (MES) | Pentylenetetrazole(PTZ)

ABSTRACT
Epilepsy is the most frequent neurodegenerative disease. It is a state of recurrent, spontaneous seizures. The present study was undertaken to evaluate the anti-convulsant activity of different extracts of Nerium oleander. Different doses of different extracts were assessed by using Maximal electro shock (MES) and Pentylene tetrazole (PTZ) induced convulsions for its anticonvulsant activity in a dose dependent manner. Anticonvulsant effect of the extracts were comparable to clinically used antiepileptic drugs Diazepam and phenytoin. The ethanolic and aqueous extracts showed significant activity in MES induced seizures by reducing tonic phase than compare to other extracts and control.The ethanolic extracts significantly delayed the onset of clonic and tonic convulsions induced by PTZ.

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