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Exploration of different polymers for use in the formulation of oral fast dissolving strips

Author(s): Kulkarni A. S., Deokule H.A. , Mane M.S. and Ghadge D. M.

Journal: Journal of Current Pharmaceutical Research
ISSN 0976-3171

Volume: 2;
Issue: 1;
Start page: 33;
Date: 2010;
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Keywords: Oral fast dissolving film | Solvent casting method | polymers

Objective: The purpose of the present investigation was to explore the different polymers for use in the formulation of fast dissolving strips.Materials & Methods: The films were prepared by solvent casting method. Prepared strips were evaluated for film forming capacity, visual appearance and disintegration time. The different polymers were explored for the formulation of strip such as HPMC E-15, HPMC K4M, HPMC E-5, PVA, PVP, Gelatin, Eudragite RL100, and Pullulan with different excipients such as carrageen, guar gum. PEG 400, Glycerin.Results: Among all polymers Pullulan and HPMC E-15 were showed desired film forming capacity.Conclusion: Very transparent visual appearance, Best film forming capacity and least disintegration time of pullulan strips were observed in the study. So, pullulan is the best film forming agent among all film forming polymers.
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