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Expression of FAS/APO 1/CD 95 in thyroid tumors.

Author(s): Marta Rzeszutko | Wojciech Rzeszutko | Piotr Dziegiel | Waldemar Balcerzak | Krzysztof Kaliszewski | Marek Bolanowski

Journal: Folia Histochemica et Cytobiologica
ISSN 0239-8508

Volume: 45;
Issue: 2;
Start page: 87;
Date: 2007;
Original page

Using immunohistochemistry, Fas/Apo-1 protein expression was investigated in thyroid cancers of 67 patients. Thyroid biopsies from twenty eight patients with benign thyroid diseases were also examined. The patients with thyroid cancer manifested a variable histology of the cancer, including 14 patients with follicular carcinoma, 48 with papillary carcinoma, 5 patients with medullary carcinoma. The benign thyroid disease involved nodular goitre in 11 patients and follicular adenoma in other 17 patients. The study aimed at examining immunohistochemical expression of Fas protein in order to determine whether the level of its expression correlated with histological diagnosis. In individual patients Fas expression was more prevalent in thyroid carcinomas as compared to benign tumors (p=0.001). A marked increase in Fas expression was found in papillary carcinoma, as compared to follicular and medullary carcinomas (p=0.02). In conclusion, Fas was significantly more frequently overexpressed in thyroid cancer, indicating its role in thyroid tumorigenesis.
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