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Expression and Its Clinical Significance of SLC22A18 in Non-small Cell Lung Cancer

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Author(s): Ming LEI | Qingshu CHENG | Yachao ZHAO | Tao LIU | Xuejiao WANG | Yingchun DENG | Jing YANG | Zhipei ZHANG

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 15;
Issue: 1;
Start page: 17;
Date: 2012;
Original page

Keywords: Lung neoplasms | SLC22A18 | Immunohistochemistry

ABSTRACT
Background and objective It has been proven that multidrug resistance (MDR) is the main cause of chemotherapy failure in lung cancer. Research on emergence mechanisms of MDR has great clinical significance in improving the curative efficiency of lung cancer chemotherapy. Proteins encoded by the SLC22A18 gene, which is similar to the transmembrane transporter, may influence the sensitivity of chemotherapeutics as well as the metabolism and growth of cells. In addition, these proteins probably have some effect on the development of lung cancer MDR. The aim of the present study is to investigate the expression of SLC22A18 protein in non-small cell lung cancer (NSCLC) as well as in corresponding normal lung tissue. Furthermore, the relationship between SLC22A18 expression and pathological grade and TNM stage is analyzed. Methods The expression of SLC22A18 was detected by EnVinsion in 96 cases with NSCLC and in corresponding normal lung tissue. Statistical analysis was performed using SPSS 17.0 statistical software. Results SLC22A18 was mainly located in cell membrane and cytoplasm. The expression level of SLC22A18 in NSCLC was significantly higher than that in normal tissue (P
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