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Expression of nicotinic acetylcholine receptors on human B-lymphoma cells

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Author(s): Omelchenko D. M. | Skok M. V.

Journal: Biopolymers and Cell
ISSN 0233-7657

Volume: 25;
Issue: 6;
Start page: 509;
Date: 2009;
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Keywords: nicotinic acetylcholine receptor | B- lymphocytes

ABSTRACT
Aim. To find a correlation between the level of nicotinic acetylcholine receptor (nAChR) expression and B lymphocyte differentiation or activation state. Methods. Expression of nAChRs in the REH, Ramos and Daudi cell lines was studied by flow cytometry using nAChR subunit-specific antibodies; cell proliferation was studied by MTT test. Results. It is shown that the level of 42/4 and 7 nAChRs expression increased along with B lymphocyte differentiation (Ramos > REH) and activation (Daudi > > Ramos) and depended on the antigen-specific receptor expression. The nAChR stimulation/blockade did not influence the intensity of cell proliferation.
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