Academic Journals Database
Disseminating quality controlled scientific knowledge

Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival

ADD TO MY LIST
 
Author(s): Huerta-Yepez Sara | Yoon Nam | Hernandez-Cueto Angeles | Mah Vei | Rivera-Pazos Clara | Chatterjee Devasis | Vega Mario | Maresh Erin | Horvath Steve | Chia David | Bonavida Benjamin | Goodglick Lee

Journal: BMC Cancer
ISSN 1471-2407

Volume: 11;
Issue: 1;
Start page: 259;
Date: 2011;
Original page

ABSTRACT
Abstract Background Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C, which leads to dissociation of RKIP from Raf-1. RKIP expression is low in many human cancers and represents an indicator of poor prognosis and/or induction of metastasis. The prognostic power has typically been based on total RKIP expression and has not considered the significance of phospho-RKIP. Methods The present study examined the expression levels of both RKIP and phospho-RKIP in human lung cancer tissue microarray proteomics technology. Results Total RKIP and phospho-RKIP expression levels were similar in normal and cancerous tissues. phospho-RKIP levels slightly decreased in metastatic lesions. However, the expression levels of phospho-RKIP, in contrast to total RKIP, displayed significant predictive power for outcome with normal expression of phospho-RKIP predicting a more favorable survival compared to lower levels (P = 0.0118); this was even more pronounced in more senior individuals and in those with early stage lung cancer. Conclusions This study examines for the first time, the expression profile of RKIP and phospho-RKIP in lung cancer. Significantly, we found that phospho-RKIP was a predictive indicator of survival.
Why do you need a reservation system?      Save time & money - Smart Internet Solutions