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Expression and Prognostic Value of VEGF-C and Lymphangeogenesis 
in Lung Adenocarcinoma and Squamous Cell Carcinoma

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Author(s): Xueli DAI | Wenli WANG | Yang SHEN-TU | Jie ZHANG

Journal: Chinese Journal of Lung Cancer
ISSN 1009-3419

Volume: 14;
Issue: 10;
Start page: 774;
Date: 2011;
Original page

Keywords: Lung neoplasms | Vascular endothelial growth factor-C | Lymphangiogenesis | Prognosis

ABSTRACT
Background and objective Vascular endothelial growth factor-C (VEGF-C), a member of the VEGF family, has been proven to be a relatively special VEGF. When binding to its receptor VEGFR-3, it activates lymphangiogenesis, which likely induces lymph node metastasis in tumors. The aim of this study is to characterize the expression and prognostic value of VEGF-C and lymphangiogenesis in lung adenocarcinoma and squamous cell carcinoma. Methods Through immunohistochemistry, the lymph vessel endothelial cells undergoing lymphangiogenesis were stained with podoplanin to detect the expression of VEGF-C and lymphangiogenesis in 98 cases with stage IIIa (N2) lung adenocarcinoma and squamous cell carcinoma. Results The expression rate of the VEGF-C was positively correlated with the lymphatic microvessel density (LMVD; r=0.783, P
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