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Expressions of tumor necrosis factor-related apoptosis-inducing ligand and caspase-3 are not predictive factors of chronic hepatitis C therapy

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Author(s): Anna Piekarska | Robert Kubiak | Aleksandra Omulecka | Wiesław Szymczak | Janusz Piekarski

Journal: Polish Gastroenterology
ISSN 1232-9886

Volume: 16;
Issue: 4;
Start page: 288;
Date: 2009;
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Keywords: apoptosis | chronic hepatitis C | caspase-3 | tumor necrosis factor-related apoptosis-inducing ligand

ABSTRACT
Introduction: TRAIL and caspase-3 may play an important role in elimination of HCV in patients with chronic hepatitis C. In our previous articles, we improved, that TRAIL and caspase-3 expression corelated with histological changes in biopsy specimen in this group of patients. Aim of the study:To assess the predictive value of liver tissue expressions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and the apoptosis effector caspase-3 in the treatment of patients with chronic hepatitis C viral infection. Material and methods:The expressions of TRAIL and caspase-3 were assessed immunohistochemically in liver biopsy specimens from 26 adults with chronic hepatitis before treatment with pegylated interferon and ribavirin. Results: The expressions of TRAIL and caspase-3 in hepatocytes were not related to viral load in patients' sera before treatment. Their expressions were also not related to the results of antiviral treatment. Conclusion: In this group of patients with chronic hepatitis C itwas not possible to predictthe results of theantiviral treatment properly solely on the basis of the expressions of TRAIL and caspase-3 in liver tissue. It seems that their expression cannot serve as a predictive factor in anti-virally treated chronic hepatitis C patients.
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