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An extensive phenotypic characterization of the hTNFα transgenic mice

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Author(s): Hayward Michael | Jones Beverly | Saparov Arman | Hain Heather | Trillat Anne-Cecile | Bunzel Michelle | Corona Aaron | Li-Wang Bifang | Strenkowski Bryan | Giordano Caroline | Shen Hai | Arcamone Emily | Weidlick Jeffrey | Vilensky Maria | Tugusheva Marina | Felkner Roland | Campbell William | Rao Yu | Grass David | Buiakova Olesia

Journal: BMC Physiology
ISSN 1472-6793

Volume: 7;
Issue: 1;
Start page: 13;
Date: 2007;
Original page

ABSTRACT
Abstract Background Tumor necrosis factor alpha (TNFα) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachexia. Transgenic mice expressing human TNFα (hTNFα) have previously been described as a model for progressive rheumatoid arthritis. In this report, we describe extensive characterization of an hTNFα transgenic mouse line. Results In addition to arthritis, these hTNFα transgenic mice demonstrated major alterations in body composition, metabolic rate, leptin levels, response to a high-fat diet, bone mineral density and content, impaired fertility and male sexual function. Many phenotypes displayed an earlier onset and a higher degree of severity in males, pointing towards a significant degree of sexual dimorphism in response to deregulated expression of TNFα. Conclusion These results highlight the potential usefulness of this transgenic model as a resource for studying the progressive effects of constitutively expressed low levels of circulating TNFα, a condition mimicking that observed in a number of human pathological conditions.
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