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Extensively drug resistant tuberculosis (XDR-TB):A potential threat

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Author(s): Anaga Marwar | Nanadal | Ivvala Anand Shaker | Hemraz Palawan | M. S. Ranjith | GokulShankar

Journal: Journal of Basic and Clinical Pharmacy
ISSN 0976-0105

Volume: 2;
Issue: 1;
Start page: 27;
Date: 2011;
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Keywords: MDR-TB | XDR-TB | resistance

ABSTRACT
Emergence of extensively drug resistant tuberculosis (XDR-TB) has been reported by more than 55 countries. XDR-TB is considered as untreatable and highly fatal disease. In developing countries like India, number of cases of multi-drug resistant tuberculosis (MDR-TB) and XDR-TB are increasing. Emergence of resistance to Isoniazid and Rifampicin, the two most effective and well tolerated agents, coupledwith resistance to second line agents pose limited treatment options for XDR-TB. The present minireview provides information about the seriousness of XDR-TB and the drugs available for its treatment. Although considered a fatal disorder, judicious use of combination of drugs, retaining their antimycobacterial activity, can improve theclinical outcome of XDR-TB. Only such an approach can provide some hope for the patients of XDR-TB.
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