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Extractive Spectrophotometric Determination of Pramipexole Dihydrochloride in Pure and Pharmaceutical Formulations

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Author(s): Thangabalan Boovizhikannan1*, Praveen kumar1, Gade Lavanya1, Shaik Inthiaz 1, Choragudi Deepthi1, Sitty Manohar Babu1, and Vijayaraj Kumar Palanirajan2

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 3;
Start page: 813;
Date: 2011;
Original page

Keywords: Pramipexole | extractive spectrophotometric determination | ion-association complex

ABSTRACT
Two simple, rapid and sensitive extractive spectrophotometric methods have been developed for the assay of pramipexole in pure and pharmaceutical formulations. These methods are based on the formationof chloroform soluble ion-association complexes of pramipexole with Bromocresol Green (BCG) and with Bromothymol blue (BTB) in potassium hydrogen phthalate buffer pH-4 with absorption maximum at 426 nm and 422 nm for BCG and BTB, respectively. Reaction conditions were optimized to obtain the maximum colour intensity. The absorbance was found to increase linearly with increase in concentration of pramipexole, which was corroborated by the calculated correlation coefficient values (0.9999 and 0.9998). The systems obeyed Beer’s law in the range of 5-25 μg/mL for BCG and BTB. Various analytical parameters have been evaluated and the results have been validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations.
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