Academic Journals Database
Disseminating quality controlled scientific knowledge

Fabrication, Modeling and Characterization of Multi-Crosslinked Methacrylate Copolymeric Nanoparticles for Oral Drug Delivery

ADD TO MY LIST
 
Author(s): Ndidi C. Ngwuluka | Viness Pillay | Yahya E. Choonara | Girish Modi | Dinesh Naidoo | Lisa C. du Toit | Pradeep Kumar | Valence M.K. Ndesendo | Riaz A. Khan

Journal: International Journal of Molecular Sciences
ISSN 1422-0067

Volume: 12;
Issue: 9;
Start page: 6194;
Date: 2011;
Original page

Keywords: nanotechnology | nanoparticles | nanocapsules | methacrylate copolymer | chitosan | oral drug delivery | bioavailability | crosslinking | molecular mechanics simulations

ABSTRACT
Nanotechnology remains the field to explore in the quest to enhance therapeutic efficacies of existing drugs. Fabrication of a methacrylate copolymer-lipid nanoparticulate (MCN) system was explored in this study for oral drug delivery of levodopa. The nanoparticles were fabricated employing multicrosslinking technology and characterized for particle size, zeta potential, morphology, structural modification, drug entrapment efficiency and in vitro drug release. Chemometric Computational (CC) modeling was conducted to deduce the mechanism of nanoparticle synthesis as well as to corroborate the experimental findings. The CC modeling deduced that the nanoparticles synthesis may have followed the mixed triangular formations or the mixed patterns. They were found to be hollow nanocapsules with a size ranging from 152 nm (methacrylate copolymer) to 321 nm (methacrylate copolymer blend) and a zeta potential range of 15.8–43.3 mV. The nanoparticles were directly compressible and it was found that the desired rate of drug release could be achieved by formulating the nanoparticles as a nanosuspension, and then directly compressing them into tablet matrices or incorporating the nanoparticles directly into polymer tablet matrices. However, sustained release of MCNs was achieved only when it was incorporated into a polymer matrix. The experimental results were well corroborated by the CC modeling. The developed technology may be potentially useful for the fabrication of multi-crosslinked polymer blend nanoparticles for oral drug delivery.
Save time & money - Smart Internet Solutions     

Tango Jona
Tangokurs Rapperswil-Jona