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FABRICATION OF SUSTAINED RELEASE MATRIX TABLETS OF VENLAFAXINE HYDROCHLORIDE USING EUDRAGITS

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Author(s): Radhika P.R | Dedeepya Karanam | Sivakumar T

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 4;
Start page: 1386;
Date: 2011;
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Keywords: Venlafaxine Hydrochloride | Sustained Release | Eudragit RLPO Eudragit RSPO | Matrix tablet.

ABSTRACT
The aim of the study was to design sustained release matrix tablets of Venlafaxine Hydrochloride using a high permeable Eudragit RLPO and low permeable Eudragit RSPO in different ratios. Tablet matrices were prepared by direct compression and were formulated as F1, F2 and. F3 by using the above mentioned polymers. Technological characterizations like thickness, diameter, weight variation test, drug content, hardness, and friability were carried out with the formulated matrix tablet. The in-vitro drug releases of the formulated tablets were measured using the USP -24 types II dissolution apparatus. The formulations showed an optimum hardness, constant weight uniformity and low friability. The kinetic release treatment showed that the release of drug follows Zero order kinetic (r2 = 0. 9965), Koresmeyer equation gave value of r2= 0.9980 which was close to one indicating that the drug was released by Zero order kinetic. The in- vitro drug release data to Koresmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release. The formulation F1 containing high quantity of Eudragit RSPO provided the slowest release profile and 90 % of the drug content was released after 18 hours than other formulations. The systematic formulation approach enabled to develop sustained release Venlafaxine Hydrochloride tablets.Further investigations are needed to confirm the in vivo efficacy and this study demonstrated that Eudragit polymer can provide controlled release.
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