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FABRICATION AND IN VITRO EVALUATION OF OSMOTIC PUMP TABLETS FOR CONTROLLED DELIVERY OF METOPROLOL TARTRATE

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Author(s): Shiva Kumar Yellanki

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 3;
Start page: 12;
Date: 2010;
Original page

Keywords: Osmotic pump | Controlled release | Metoprolol Tartrate.

ABSTRACT
The aim of the current study was to design a porous osmotic pump-based drug delivery system for controlled release of Metoprolol Tartrate. Based on the principles of an elementary osmotic pump (OP), OP tablets were designed and evaluated with the aim to deliver Metoprolol Tartrate (MT) in a controlled manner. The tablets were prepared by direct compression method. Effects of coating thickness, surface porosity and viscolyzing polymer were studied. Optimization results indicated that MT release was inversely proportional to the membrane thickness and viscolyzing polymer; however directly proportional to the surface porosity of the membrane, respectively. It was concluded that the osmotic pump tablets could provide more prolonged and controlled MT release that may result in an improved therapeutic efficacy and patient compliance
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