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Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

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Author(s): Yong-Mei Xie | Yu-Qin Yao | Hong-Bao Sun | Ting-Ting Yan | Jie Liu | Tai-Ran Kang

Journal: Molecules
ISSN 1420-3049

Volume: 16;
Issue: 10;
Start page: 8745;
Date: 2011;
Original page

Keywords: spiropyrrolizidine oxindoles | cycloaddition | isatin

ABSTRACT
An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
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Tango Jona
Tangokurs Rapperswil-Jona