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The FAGenomicH project: towards a whole candidate gene approach to identify markers associated with fatness and production traits in pigs and investigate the pig as a model for human obesity

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Author(s): Luca Fontanesi | Raffaele Fronza | Emilio Scotti | Michela Colombo | Camilla Speroni | Lucia Tognazzi | Giuliano Galimberti | Daniela Giovanna Calò | Elena Bonora | Manuela Vargiolu | Giovanni Romeo | Rita Casadio | Vincenzo Russo

Journal: Italian Journal of Animal Science
ISSN 1594-4077

Volume: 8;
Issue: 2s;
Start page: 87;
Date: 2010;
Original page

Keywords: Pig | Fatness | Obesity | Candidate genes.

ABSTRACT
Fatness in pigs is a complex trait for which a large number of genes are expected to be involved. Genetics of human obesity could take advantages from genetic information coming from the pig and vice versa. To these aims, a comprehensive candidate gene approach could be helpful. We catalogued all genes affecting fatness on both species, and identified in silico and by resequencing porcine SNPs on a large number of candidate genes. In addition, we applied a selective genotyping approach to identify markers associated with fat deposition in pigs. This approach was tested genotyping the IGF2 intron3-g.3072G>A mutation and novel markers in the PCSK1 and TBC1D1 genes. Polymorphisms in these genes resulted associated with back fat thickness in Italian Large White pigs.
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Tango Rapperswil
Tango Rapperswil