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Familial Sarcoidosis: About Two Brothers and Prevalence Value in a Middle Eastern City

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Author(s): Georges Khalil | Grace Obeid | Elie Mansour | Georges Nawfal

Journal: International Journal of Collaborative Research on Internal Medicine & Public Health
ISSN 1840-4529

Volume: 3;
Issue: 8;
Start page: 650;
Date: 2011;
Original page

Keywords: Sarcoidosis | familial | Lebanese | HLA DR B

ABSTRACT
Sarcoidosis is a systemic disease with no definite etiology, but a lot of potential precipitating factors. Familial sarcoidosis was mentioned in the literature long time ago and has been associated with different HLA phenotypes with a prevalence reaching values up to 4% and more; however, it was never studied in the Middle East. This article reports a case of sarcoidosis in two Lebanese brothers with the HLA phenotype related and estimates the prevalence of familial sarcoidosis in all cases of sarcoidosis treated by internists and pneumologists in a regional hospital where these brothers were treated. In our study, the HLA type (DRB) was similar to the familial polish cases and the familial prevalence of around 1.4 %, was much lower than that reported elsewhere.

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