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Feasibility of biological monitoring for evaluating of exposure to Cr6 in Electroplating workshops

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Author(s): F Golbabaie | M Ostadi | V Ostadi | M Rismanchian | A Tirgar | SJ Sahtahery

Journal: Journal of School of Public Health and Institute of Public Health Research
ISSN 1735-7586

Volume: 5;
Issue: 3;
Start page: 15;
Date: 2007;
Original page

Keywords: Hexavalent chromium | Electroplating | β2 microglobulin | N-acetyl-B-D- glucosaminidase | Biological monitoring | Renal dysfunction

ABSTRACT
Background and Aim: Exposure to hexavalent chromium in plating operations is associated with skin ulceration, contact dermatitis, respiratory tract irritation, cancer, and kidney damage. We investigated the possibility of using biological monitoring to assess exposure to hexavalent chromium in chrome-plating workers. We compared mean Cr6 concentrations in the breathing zone plus urine chromium, β2 microglobulin (B2M), and N-acetyl-B-D- glucosaminidase (NAG) at the end of the working shift. Then we assessed the correlation between exposure to hexavalent chromium and biological indicators."nMaterials and Methods: This study involved 45 chrome platers (Cases) and 40 zinc platers (Controls) in Isfahan. Air and urine samples were collected at the end of the work shift. Measurement of Cr6 concentrations in the workers' breathing zone was performed using the NIOSH Methods 7600. Urine Cr levels were determined by atomic absorption spectrophotometry, with a graphite furnace (Shimadsu, AA680). B2M and NAG were measured by Kits."nResults: Overall, geometric mean of hexavalent chromium concentrations in the breathing zone was significantly higher among chrome platers (14.577 μg/m3) compared to zinc platers (0.862 μg/m3, p

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