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Feasibility of incorporating genomic knowledge into electronic medical records for pharmacogenomic clinical decision support

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Author(s): Overby Casey | Tarczy-Hornoch Peter | Hoath James | Kalet Ira | Veenstra David

Journal: BMC Bioinformatics
ISSN 1471-2105

Volume: 11;
Issue: Suppl 9;
Start page: S10;
Date: 2010;
Original page

ABSTRACT
Abstract In pursuing personalized medicine, pharmacogenomic (PGx) knowledge may help guide prescribing drugs based on a person’s genotype. Here we evaluate the feasibility of incorporating PGx knowledge, combined with clinical data, to support clinical decision-making by: 1) analyzing clinically relevant knowledge contained in PGx knowledge resources; 2) evaluating the feasibility of a rule-based framework to support formal representation of clinically relevant knowledge contained in PGx knowledge resources; and, 3) evaluating the ability of an electronic medical record/electronic health record (EMR/EHR) to provide computable forms of clinical data needed for PGx clinical decision support. Findings suggest that the PharmGKB is a good source for PGx knowledge to supplement information contained in FDA approved drug labels. Furthermore, we found that with supporting knowledge (e.g. IF age
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