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Features of rat skin structure in norm and at pyrogenalum action

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Author(s): Shapovalov D.A. | Golub A.P.

Journal: Морфологія
ISSN 1997-9665

Volume: 2;
Issue: 2;
Start page: 71;
Date: 2008;
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Keywords: skin | rats | Pyrogenalum

ABSTRACT
On 48 rats-males of genesial age in mass 140-210, which have been parted on four groups: 1 group – control; 2, 3, 4 groups – experimental (entered Pyrogenalum in a dose of 3,0 mg/kg once a day throughout the days two and three accordingly) features of a structure of a skin in norm have been studied and at Pyrogenalum introduction. The microscopic sections of a skin received in two is mutual perpendicular planes, dyed by hematoxylin-eosin and Mallory-Slinchenko's method. The obtained quantitative data processed with use of methods of variation statistics. After intraperitoneal introduction of Pyrogenalum in a dose of 3,0 mg / kg of change of a structure of a skin occur in all регионально various sites. They consist in augmentation of a thickness of separate layers of a skin, augmentation of diameter of lead-out ducts потовых glands, edemas of tissues, reduction of density of collagen fibers. To the greatest changes at a hyperthermia a vascular bed of a skin which are most expressed at early o'clock after Pyrogenalum introduction. At secondary introductions of Pyrogenalum of rasping changes in a skin does not occur and for 7 8 days the skin structure is similar to a skin of control group of animals.
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