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Five New Amicoumacins Isolated from a Marine-Derived Bacterium Bacillus subtilis

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Author(s): Yongxin Li | Ying Xu | Lingli Liu | Zhuang Han | Pok Yui Lai | Xiangrong Guo | Xixiang Zhang | Wenhan Lin | Pei-Yuan Qian

Journal: Marine Drugs
ISSN 1660-3397

Volume: 10;
Issue: 2;
Start page: 319;
Date: 2012;
Original page

Keywords: antibacterial | cytotoxicity | lipoamicoumacin | Bacillus subtilis

ABSTRACT
Four novel amicoumacins, namely lipoamicoumacins A–D (1–4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.
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