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Flavonoids of puerarin versus tanshinone ⅡA for ischemic stroke: a randomized controlled trial

Author(s): Lei Chen

Journal: Zhong Xi Yi Jie He Xue Bao
ISSN 1672-1977

Volume: 9;
Issue: 11;
Start page: 1215;
Date: 2011;
Original page

Keywords: puerarin | flavone | tanshinone | brain ischemia | stroke | lactate dehydrogenases | interleukin-6 | brain-derived neurotrophic factor

Background: Flavonoids are widely used today in the treatment of ischemic stroke. The therapeutic effects and functions of flavonoids are, therefore, generating more and more interest.Objective: To investigate the therapeutic effects and functions of flavonoids of puerarin in treating patients with ischemic stroke.Design, setting, participants and interventions: A total of 67 inpatients suffering from ischemic stroke from the Department of Neurology, Changhai Hospital in China were divided into two groups randomly, the treatment group, which was treated with flavonoids of puerarin, and the control group, administered with tanshinone ⅡA sulfate instead. Main outcome measures: Defects in neurological function were evaluated according to the National Institutes of Health Stroke Scale (NIHSS) on the first day of onset. Lactate dehydrogenase (LDH), serum interleukin-6 (IL-6) and brain-derived neurotrophic factor (BDNF) levels were determined by radioimmunoassay on the second trial day. After a 14-day treatment, LDH, serum IL-6 and BDNF levels and NIHSS score were also detected, and CT perfusion imaging was used to measure and analyze the regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and mean transit time (MTT).Results: On the first day, NIHSS scores of the two groups were similar. On the second day there was no significant difference in LDH and IL-6 levels between the treatment group and the control group. After a 14-day treatment, LDH and IL-6 levels and the NIHSS score in the treatment group were lower than those in the control group (P
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