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FLT3/ITD associated with an immature immunophenotype in PML-RARα leukemia

Author(s): Mariko Takenokuchi | Seiji Kawano | Yuji Nakamachi | Yasuyuki Sakota | Meilani Syampurnawati | Katsuyasu Saigo | Eiji Tatsumi | Shunichi Kumagai

Journal: Hematology Reports
ISSN 2038-8322

Volume: 4;
Issue: 3;
Date: 2012;
Original page

Keywords: FLT3/ITD | FLT3/ D835 | CD2 | immature phenotype

Acute promyelocytic leukemia (APL) is characterized by the specific PML-RARα fusion gene resulting from translocation t(15;17)(q22;q12). Internal tandem duplication (ITD) of the FLT3 gene has been observed in about 35% of APLs, and large-scale studies have identified the presence of ITD as an adverse prognostic factor for AML patients. Aberrant expressions of surface antigens such as CD2, CD34, and CD56 have been found in APL, but their implication is not well understood. We investigated the incidence of the FLT3/ITD mutation and FLT3/D835 (I836) point mutation in 25 APL patients. Incidence ratios of FLT3/ITD, D835 (I836), and both FLT3/ITD and D835 (I836) were 36, 36, and 8%, respectively. FLT3/ITD+ cases showed a predominance of the bcr3 isoform (p=0.008) and M3v morphology (p
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